Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2018-11-07 | Bethune-Cookman (285) | 58 | 80 | DePaul (122) | Final | W | 22 |
| 2 | 2018-11-12 | Morgan State (329) | 63 | 91 | DePaul (122) | Final | W | 28 |
| 3 | 2018-11-15 | Penn State (106) | 70 | 72 | DePaul (107) | Final/OT | W | 2 |
| 4 | 2018-11-24 | DePaul (50) | 70 | 95 | Notre Dame (103) | Final | L | -25 |
| 5 | 2018-11-28 | Cleveland State (275) | 73 | 83 | DePaul (85) | Final | W | 10 |
| 6 | 2018-12-03 | Florida A&M (284) | 50 | 65 | DePaul (85) | Final | W | 15 |
| 7 | 2018-12-08 | DePaul (78) | 68 | 75 | Northwestern (69) | Final | L | -7 |
| 8 | 2018-12-12 | Chicago State (327) | 70 | 104 | DePaul (103) | Final | W | 34 |
| 9 | 2018-12-14 | Illinois-Chicago (194) | 70 | 90 | DePaul (103) | Final | W | 20 |
| 10 | 2018-12-19 | Incarnate Word (323) | 71 | 81 | DePaul (88) | Final | W | 10 |
| 11 | 2018-12-22 | Boston College (75) | 65 | 62 | DePaul (88) | Final | L | -3 |
| 12 | 2018-12-29 | Xavier (81) | 74 | 65 | DePaul (105) | Final | L | -9 |
| 13 | 2019-01-02 | DePaul (126) | 68 | 73 | Villanova (36) | Final | L | -5 |
| 14 | 2019-01-06 | Seton Hall (33) | 74 | 75 | DePaul (126) | Final | W | 1 |
| 15 | 2019-01-12 | DePaul (116) | 79 | 71 | St. John's (16) | Final | W | 8 |
| 16 | 2019-01-16 | Butler (56) | 87 | 69 | DePaul (91) | Final | L | -18 |
| 17 | 2019-01-19 | DePaul (91) | 97 | 93 | Seton Hall (39) | Final | W | 4 |
| 18 | 2019-01-23 | DePaul (91) | 69 | 79 | Marquette (13) | Final | L | -10 |
| 19 | 2019-01-27 | DePaul (91) | 67 | 70 | Providence (81) | Final | L | -3 |
| 20 | 2019-01-30 | Villanova (17) | 86 | 74 | DePaul (106) | Final | L | -12 |
| 21 | 2019-02-02 | Providence (66) | 55 | 67 | DePaul (106) | Final | W | 12 |
| 22 | 2019-02-09 | DePaul (99) | 74 | 62 | Xavier (97) | Final | W | 12 |
| 23 | 2019-02-12 | Marquette (13) | 92 | 73 | DePaul (86) | Final | L | -19 |
| 24 | 2019-02-16 | DePaul (86) | 78 | 91 | Butler (58) | Final | L | -13 |
| 25 | 2019-02-20 | Creighton (65) | 79 | 67 | DePaul (98) | Final | L | -12 |
| 26 | 2019-02-27 | DePaul (103) | 73 | 82 | Georgetown (67) | Final | L | -9 |
| 27 | 2019-03-03 | St. John's (40) | 83 | 92 | DePaul (103) | Final | W | 9 |
| 28 | 2019-03-06 | Georgetown (62) | 69 | 101 | DePaul (98) | Final | W | 32 |
| 29 | 2019-03-09 | DePaul (98) | 78 | 91 | Creighton (55) | Final | L | -13 |
| 30 | 2019-03-13 | DePaul (94) | 74 | 82 | St. John's (55) | Final | L | -8 |