Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2018-11-06 | The Citadel (298) | 80 | 100 | Clemson (21) | Final | W | 20 |
| 2 | 2018-11-09 | North Carolina Central (287) | 51 | 71 | Clemson (21) | Final | W | 20 |
| 3 | 2018-11-14 | Sam Houston State (227) | 59 | 74 | Clemson (32) | Final | W | 15 |
| 4 | 2018-11-19 | Akron (116) | 69 | 72 | Clemson (32) | Final | W | 3 |
| 5 | 2018-11-20 | Clemson (51) | 64 | 49 | Georgia (123) | Final | W | 15 |
| 6 | 2018-11-21 | Clemson (51) | 82 | 87 | Creighton (113) | Final | L | -5 |
| 7 | 2018-11-26 | Nebraska (11) | 68 | 66 | Clemson (51) | Final | L | -2 |
| 8 | 2018-12-04 | Saint Peter’s (289) | 60 | 65 | Clemson (49) | Final | W | 5 |
| 9 | 2018-12-08 | Clemson (49) | 71 | 82 | Mississippi State (35) | Final | L | -11 |
| 10 | 2018-12-15 | Radford (129) | 66 | 74 | Clemson (80) | Final | W | 8 |
| 11 | 2018-12-18 | Charleston Southern (296) | 51 | 78 | Clemson (64) | Final | W | 27 |
| 12 | 2018-12-22 | Clemson (64) | 78 | 68 | South Carolina (176) | Final | W | 10 |
| 13 | 2018-12-30 | Lipscomb (43) | 67 | 84 | Clemson (56) | Final | W | 17 |
| 14 | 2019-01-05 | Clemson (43) | 68 | 87 | Duke (1) | Final | L | -19 |
| 15 | 2019-01-09 | Clemson (48) | 53 | 61 | Syracuse (54) | Final | L | -8 |
| 16 | 2019-01-12 | Virginia (2) | 63 | 43 | Clemson (48) | Final | L | -20 |
| 17 | 2019-01-16 | Georgia Tech (79) | 60 | 72 | Clemson (54) | Final | W | 12 |
| 18 | 2019-01-22 | Clemson (54) | 68 | 77 | Florida State (33) | Final | L | -9 |
| 19 | 2019-01-26 | Clemson (54) | 67 | 69 | North Carolina State (32) | Final | L | -2 |
| 20 | 2019-01-29 | Pittsburgh (67) | 69 | 82 | Clemson (60) | Final | W | 13 |
| 21 | 2019-02-03 | Wake Forest (160) | 37 | 64 | Clemson (60) | Final | W | 27 |
| 22 | 2019-02-06 | Clemson (50) | 65 | 42 | Georgia Tech (91) | Final | W | 23 |
| 23 | 2019-02-09 | Virginia Tech (11) | 51 | 59 | Clemson (50) | Final | W | 8 |
| 24 | 2019-02-13 | Clemson (38) | 64 | 65 | Miami (91) | Final | L | -1 |
| 25 | 2019-02-16 | Clemson (38) | 55 | 56 | Louisville (17) | Final | L | -1 |
| 26 | 2019-02-19 | Florida State (16) | 77 | 64 | Clemson (47) | Final | L | -13 |
| 27 | 2019-02-23 | Boston College (100) | 66 | 76 | Clemson (47) | Final | W | 10 |
| 28 | 2019-02-27 | Clemson (45) | 62 | 48 | Pittsburgh (114) | Final | W | 14 |
| 29 | 2019-03-02 | North Carolina (5) | 81 | 79 | Clemson (45) | Final | L | -2 |
| 30 | 2019-03-06 | Clemson (44) | 64 | 62 | Notre Dame (94) | Final | W | 2 |
| 31 | 2019-03-09 | Syracuse (34) | 55 | 67 | Clemson (44) | Final | W | 12 |
| 32 | 2019-03-13 | Clemson (36) | 58 | 59 | North Carolina State (32) | Final | L | -1 |
| 33 | 2019-03-19 | Wright State (142) | 69 | 75 | Clemson (40) | Final | W | 6 |
| 34 | 2019-03-24 | Wichita State (76) | 63 | 55 | Clemson (40) | Final | L | -8 |