Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-25 | Liberty (77) | 64 | 77 | Purdue (46) | Final | L | -13 |
| 2 | 2020-11-26 | Purdue (46) | 70 | 81 | Clemson (74) | Final | L | -11 |
| 3 | 2020-12-01 | Oakland (352) | 50 | 93 | Purdue (108) | Final | L | -43 |
| 4 | 2020-12-04 | Valparaiso (283) | 61 | 68 | Purdue (108) | Final | L | -7 |
| 5 | 2020-12-08 | Purdue (49) | 54 | 58 | Miami (79) | Final | L | -4 |
| 6 | 2020-12-12 | Indiana State (176) | 68 | 80 | Purdue (49) | Final | L | -12 |
| 7 | 2020-12-16 | Ohio State (28) | 60 | 67 | Purdue (70) | Final | L | -7 |
| 8 | 2020-12-19 | Purdue (70) | 88 | 78 | Notre Dame (125) | Final | L | -10 |
| 9 | 2020-12-22 | Purdue (49) | 55 | 70 | Iowa (13) | Final | L | -15 |
| 10 | 2020-12-25 | Maryland (29) | 70 | 73 | Purdue (49) | Final | L | -3 |
| 11 | 2020-12-29 | Purdue (44) | 76 | 81 | Rutgers (14) | Final | L | -5 |
| 12 | 2021-01-02 | Purdue (44) | 58 | 66 | Illinois (13) | Final | L | -8 |
| 13 | 2021-01-05 | Nebraska (155) | 0 | 0 | Purdue (53) | Scheduled - 07:00PM ET | - | - |
| 14 | 2021-01-08 | Purdue (53) | 55 | 54 | Michigan State (78) | Final | L | -1 |
| 15 | 2021-01-14 | Purdue (45) | 81 | 69 | Indiana (37) | Final | L | -12 |
| 16 | 2021-01-17 | Penn State (74) | 72 | 80 | Purdue (41) | Final | L | -8 |
| 17 | 2021-01-19 | Purdue (41) | 67 | 65 | Ohio State (20) | Final | L | -2 |
| 18 | 2021-01-22 | Michigan (4) | 70 | 53 | Purdue (41) | Final | L | -17 |
| 19 | 2021-01-30 | Minnesota (21) | 62 | 81 | Purdue (39) | Final | L | -19 |
| 20 | 2021-02-02 | Purdue (27) | 60 | 61 | Maryland (51) | Final | L | -1 |
| 21 | 2021-02-06 | Northwestern (90) | 70 | 75 | Purdue (27) | Final | L | -5 |
| 22 | 2021-02-11 | Purdue (24) | 68 | 71 | Minnesota (36) | Final | L | -3 |
| 23 | 2021-02-16 | Michigan State (76) | 65 | 75 | Purdue (32) | Final | L | -10 |
| 24 | 2021-02-20 | Purdue (32) | 75 | 58 | Nebraska (156) | Final | L | -17 |
| 25 | 2021-02-26 | Purdue (26) | 73 | 52 | Penn State (67) | Final | L | -21 |
| 26 | 2021-03-02 | Wisconsin (24) | 69 | 73 | Purdue (25) | Final | L | -4 |
| 27 | 2021-03-06 | Indiana (52) | 58 | 67 | Purdue (25) | Final | L | -9 |
| 28 | 2021-03-12 | Ohio State (9) | 87 | 78 | Purdue (19) | Final (OT) | L | -9 |
| 29 | 2021-03-19 | North Texas (77) | 78 | 69 | Purdue (22) | Final (OT) | L | -9 |