Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-11 | Charleston Southern | 38 | The Citadel | 21 | Final | W | 17 |
| 2 | 2021-09-18 | Monmouth | 41 | Charleston Southern | 14 | Final | L | -27 |
| 3 | 2021-09-25 | Charleston Southern | 28 | East Carolina | 31 | Final | L | -3 |
| 4 | 2021-10-09 | Charleston Southern | 24 | Robert Morris | 31 | Final | L | -7 |
| 5 | 2021-10-16 | Hampton | 5 | Charleston Southern | 35 | Final | W | 30 |
| 6 | 2021-10-23 | Charleston Southern | 22 | North Alabama | 45 | Final | L | -23 |
| 7 | 2021-10-30 | Campbell | 14 | Charleston Southern | 27 | Final | W | 13 |
| 8 | 2021-11-06 | North Carolina A&T | 21 | Charleston Southern | 18 | Final | L | -3 |
| 9 | 2021-11-13 | Charleston Southern | 32 | Gardner-Webb | 24 | Final(OT) | W | 8 |
| 10 | 2021-11-20 | Charleston Southern | 7 | Georgia | 56 | Final | L | -49 |