Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2024-08-31 | Austin Peay (154) | 0 | Louisville (18) | 62 | Final | W | 62 |
| 2 | 2024-09-07 | Jacksonville State (63) | 14 | Louisville (18) | 49 | Final | W | 35 |
| 3 | 2024-09-21 | Georgia Tech (55) | 19 | Louisville (13) | 31 | Final | W | 12 |
| 4 | 2024-09-28 | Louisville (34) | 24 | Notre Dame (20) | 31 | Final | L | -7 |
| 5 | 2024-10-05 | SMU (16) | 34 | Louisville (39) | 27 | Final | L | -7 |
| 6 | 2024-10-12 | Louisville (25) | 24 | Virginia (51) | 20 | Final | W | 4 |
| 7 | 2024-10-19 | Miami (3) | 52 | Louisville (27) | 45 | Final | L | -7 |
| 8 | 2024-10-25 | Louisville (23) | 31 | Boston College (58) | 27 | Final | W | 4 |
| 9 | 2024-11-02 | Louisville (18) | 33 | Clemson (23) | 21 | Final | W | 12 |
| 10 | 2024-11-16 | Louisville (22) | 35 | Stanford (97) | 38 | Final | L | -3 |
| 11 | 2024-11-23 | Pittsburgh (36) | 9 | Louisville (17) | 37 | Final | W | 28 |
| 12 | 2024-11-30 | Louisville (15) | 41 | Kentucky (66) | 14 | Final | W | 27 |
| 13 | 2024-12-31 | Louisville (20) | 35 | Washington (49) | 34 | Final | W | 1 |