Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-09-02 | Virginia Tech (76) | 17 | Old Dominion (98) | 20 | Final | L | -3 |
| 2 | 2022-09-10 | Boston College (79) | 10 | Virginia Tech (76) | 27 | Final | W | 17 |
| 3 | 2022-09-17 | Wofford (236) | 7 | Virginia Tech (81) | 27 | Final | W | 20 |
| 4 | 2022-09-22 | West Virginia (65) | 33 | Virginia Tech (99) | 10 | Final | L | -23 |
| 5 | 2022-10-01 | Virginia Tech (105) | 10 | North Carolina (42) | 41 | Final | L | -31 |
| 6 | 2022-10-08 | Virginia Tech (116) | 29 | Pittsburgh (51) | 45 | Final | L | -16 |
| 7 | 2022-10-15 | Miami (79) | 20 | Virginia Tech (119) | 14 | Final | L | -6 |
| 8 | 2022-10-27 | Virginia Tech (120) | 21 | North Carolina State (18) | 22 | Final | L | -1 |
| 9 | 2022-11-05 | Georgia Tech (80) | 28 | Virginia Tech (125) | 27 | Final | L | -1 |
| 10 | 2022-11-12 | Virginia Tech (128) | 7 | Duke (53) | 24 | Final | L | -17 |
| 11 | 2022-11-19 | Virginia Tech (120) | 23 | Liberty (57) | 22 | Final | W | 1 |
| 12 | 2022-11-26 | Virginia | 0 | Virginia Tech | 0 | Scheduled – TBA | – | – |