Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-09-03 | South Alabama (130) | 32 | Southern Miss (79) | 21 | Final | L | -11 |
| 2 | 2020-09-19 | Louisiana Tech (53) | 31 | Southern Miss (79) | 30 | Final | L | -1 |
| 3 | 2020-09-26 | Tulane (44) | 66 | Southern Miss (79) | 24 | Final | L | -42 |
| 4 | 2020-10-03 | Southern Miss (129) | 41 | North Texas (107) | 31 | Final | W | 10 |
| 5 | 2020-10-10 | Florida Atlantic (27) | 0 | Southern Miss (122) | 0 | Scheduled – 04:00PM ET | – | – |
| 6 | 2020-10-17 | Southern Miss (123) | 0 | UTEP (120) | 0 | Scheduled – 07:30PM ET | – | – |
| 7 | 2020-10-24 | Southern Miss (119) | 35 | Liberty (18) | 56 | Final | L | -21 |
| 8 | 2020-10-31 | Rice (122) | 30 | Southern Miss (123) | 6 | Final | L | -24 |
| 9 | 2020-11-07 | North Alabama (250) | 13 | Southern Miss (126) | 24 | Final | W | 11 |
| 10 | 2020-11-14 | Southern Miss (123) | 7 | Western Kentucky (113) | 10 | Final | L | -3 |
| 11 | 2020-11-21 | UTSA (73) | 23 | Southern Miss (126) | 20 | Final | L | -3 |
| 12 | 2020-11-27 | Southern Miss (126) | 0 | UAB (53) | 0 | Scheduled – 12:30PM ET | – | – |
| 13 | 2020-12-04 | Southern Miss (125) | 0 | UTEP (118) | 0 | Scheduled – 08:00PM ET | – | – |
| 14 | 2020-12-10 | Florida Atlantic (55) | 31 | Southern Miss (121) | 45 | Final | W | 14 |