Schedule:
| Game | Date | Away Team (Rank) | Away Score | Home Team (Rank) | Home Score | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-09-04 | Campbell | 7 | Liberty | 48 | Final | W | 41 |
| 2 | 2021-09-11 | Liberty | 21 | Troy | 13 | Final | W | 8 |
| 3 | 2021-09-18 | Old Dominion | 17 | Liberty | 45 | Final | W | 28 |
| 4 | 2021-09-24 | Liberty | 21 | Syracuse | 24 | Final | L | -3 |
| 5 | 2021-10-02 | Liberty | 36 | UAB | 12 | Final | W | 24 |
| 6 | 2021-10-09 | Middle Tennessee | 13 | Liberty | 41 | Final | W | 28 |
| 7 | 2021-10-16 | Liberty | 28 | Louisiana-Monroe | 31 | Final | L | -3 |
| 8 | 2021-10-23 | Liberty | 35 | North Texas | 26 | Final | W | 9 |
| 9 | 2021-10-30 | Massachusetts | 17 | Liberty | 62 | Final | W | 45 |
| 10 | 2021-11-06 | Liberty | 14 | Ole Miss | 27 | Final | L | -13 |
| 11 | 2021-11-20 | Louisiana | 42 | Liberty | 14 | Final | L | -28 |
| 12 | 2021-11-27 | Army (36) | 31 | Liberty (63) | 16 | Final | L | -15 |
| 13 | 2021-12-18 | Eastern Michigan (87) | 20 | Liberty (53) | 56 | Final | W | 36 |