Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-11-07 | The Citadel (318) | 69 | 80 | Clemson (63) | Final | W | 11 |
| 2 | 2022-11-11 | Clemson (63) | 58 | 60 | South Carolina (197) | Final | L | -2 |
| 3 | 2022-11-15 | South Carolina Upstate (253) | 70 | 81 | Clemson (63) | Final | W | 11 |
| 4 | 2022-11-18 | Bellarmine (231) | 66 | 76 | Clemson (63) | Final | W | 10 |
| 5 | 2022-11-21 | Loyola-Maryland (328) | 41 | 72 | Clemson (63) | Final | W | 31 |
| 6 | 2022-11-25 | Iowa (43) | 74 | 71 | Clemson (63) | Final | L | -3 |
| 7 | 2022-11-26 | Clemson (63) | 67 | 59 | California (299) | Final | W | 8 |
| 8 | 2022-11-29 | Penn State (54) | 94 | 101 | Clemson (63) | Final | W | 7 |
| 9 | 2022-12-02 | Wake Forest (59) | 57 | 77 | Clemson (63) | Final | W | 20 |
| 10 | 2022-12-07 | Towson (147) | 75 | 80 | Clemson (63) | Final | W | 5 |
| 11 | 2022-12-10 | Loyola-Chicago (245) | 76 | 58 | Clemson (63) | Final | L | -18 |
| 12 | 2022-12-17 | Richmond (157) | 57 | 85 | Clemson (63) | Final | W | 28 |
| 13 | 2022-12-21 | Clemson (63) | 79 | 66 | Georgia Tech (168) | Final | W | 13 |
| 14 | 2022-12-30 | North Carolina State (26) | 64 | 78 | Clemson (63) | Final | W | 14 |
| 15 | 2023-01-04 | Clemson (63) | 68 | 65 | Virginia Tech (66) | Final | W | 3 |
| 16 | 2023-01-07 | Clemson (63) | 75 | 74 | Pittsburgh (46) | Final | W | 1 |
| 17 | 2023-01-11 | Louisville (287) | 70 | 83 | Clemson (63) | Final | W | 13 |
| 18 | 2023-01-14 | Duke (25) | 64 | 72 | Clemson (63) | Final | W | 8 |
| 19 | 2023-01-17 | Clemson (63) | 77 | 87 | Wake Forest (59) | Final | L | -10 |
| 20 | 2023-01-21 | Virginia Tech (66) | 50 | 51 | Clemson (63) | Final | W | 1 |
| 21 | 2023-01-24 | Georgia Tech (168) | 51 | 72 | Clemson (63) | Final | W | 21 |
| 22 | 2023-01-28 | Clemson (63) | 82 | 81 | Florida State (209) | Final | W | 1 |
| 23 | 2023-01-31 | Clemson (63) | 54 | 62 | Boston College (142) | Final | L | -8 |
| 24 | 2023-02-04 | Miami (16) | 78 | 74 | Clemson (63) | Final | L | -4 |
| 25 | 2023-02-11 | Clemson (63) | 71 | 91 | North Carolina (47) | Final | L | -20 |
| 26 | 2023-02-15 | Florida State (209) | 54 | 94 | Clemson (63) | Final | W | 40 |
| 27 | 2023-02-18 | Clemson (63) | 73 | 83 | Louisville (287) | Final | L | -10 |
| 28 | 2023-02-22 | Syracuse (91) | 73 | 91 | Clemson (54) | Final | W | 18 |
| 29 | 2023-02-25 | Clemson (49) | 96 | 71 | North Carolina State (32) | Final | W | 25 |
| 30 | 2023-02-28 | Clemson (53) | 57 | 64 | Virginia (16) | Final | L | -7 |
| 31 | 2023-03-04 | Notre Dame (163) | 64 | 87 | Clemson (50) | Final | W | 23 |
| 32 | 2023-03-09 | North Carolina State (37) | 54 | 80 | Clemson (44) | Final | W | 26 |
| 33 | 2023-03-10 | Clemson (44) | 56 | 76 | Virginia (16) | Final | L | -20 |
| 34 | 2023-03-15 | Morehead State | 68 | 64 | Clemson | Final | L | -4 |