Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-05 | Central Oklahoma | 68 | 76 | Oklahoma State (14) | Final | W | 8 |
| 2 | 2021-11-09 | Texas-Arlington (224) | 45 | 88 | Oklahoma State (14) | Final | W | 43 |
| 3 | 2021-11-12 | Oakland (250) | 56 | 55 | Oklahoma State (14) | Final | L | -1 |
| 4 | 2021-11-14 | Prairie View A&M (349) | 59 | 72 | Oklahoma State (131) | Final | W | 13 |
| 5 | 2021-11-16 | UMass-Lowell (93) | 58 | 80 | Oklahoma State (131) | Final | W | 22 |
| 6 | 2021-11-17 | Oklahoma State (131) | 74 | 68 | North Carolina State (75) | Final | W | 6 |
| 7 | 2021-11-22 | Charleston (130) | 66 | 96 | Oklahoma State (62) | Final | W | 30 |
| 8 | 2021-11-26 | Oklahoma State (62) | 78 | 77 | Oral Roberts (256) | Final (OT) | W | 1 |
| 9 | 2021-12-01 | Wichita State (41) | 60 | 51 | Oklahoma State (25) | Final | L | -9 |
| 10 | 2021-12-05 | Xavier (14) | 77 | 71 | Oklahoma State (25) | Final | L | -6 |
| 11 | 2021-12-13 | Cleveland State (188) | 93 | 98 | Oklahoma State (56) | Final (OT) | W | 5 |
| 12 | 2021-12-18 | Oklahoma State (56) | 61 | 72 | Houston (19) | Final | L | -11 |
| 13 | 2021-12-21 | Oklahoma State | 0 | 0 | USC | Scheduled – | – | – |
| 14 | 2022-01-04 | Kansas (6) | 74 | 63 | Oklahoma State (65) | Final | L | -11 |
| 15 | 2022-01-08 | Texas (24) | 51 | 64 | Oklahoma State (65) | Final | W | 13 |
| 16 | 2022-01-11 | Oklahoma State (55) | 60 | 70 | West Virginia (27) | Final | L | -10 |
| 17 | 2022-01-13 | Oklahoma State (55) | 57 | 78 | Texas Tech (29) | Final | L | -21 |
| 18 | 2022-01-15 | Oklahoma State (55) | 61 | 54 | Baylor (1) | Final | W | 7 |
| 19 | 2022-01-19 | TCU (34) | 56 | 57 | Oklahoma State (53) | Final | W | 1 |
| 20 | 2022-01-22 | Oklahoma State (53) | 51 | 56 | Texas (31) | Final | L | -5 |
| 21 | 2022-01-26 | Iowa State (26) | 84 | 81 | Oklahoma State (55) | Final (OT) | L | -3 |
| 22 | 2022-01-29 | Oklahoma State (65) | 72 | 81 | Florida (50) | Final | L | -9 |
| 23 | 2022-02-02 | Oklahoma State (65) | 68 | 71 | Kansas State (86) | Final | L | -3 |
| 24 | 2022-02-05 | Oklahoma (41) | 55 | 64 | Oklahoma State (65) | Final | W | 9 |
| 25 | 2022-02-08 | Oklahoma State (66) | 73 | 77 | TCU (40) | Final | L | -4 |
| 26 | 2022-02-12 | West Virginia (47) | 58 | 81 | Oklahoma State (66) | Final | W | 23 |
| 27 | 2022-02-14 | Oklahoma State (66) | 62 | 76 | Kansas (6) | Final | L | -14 |
| 28 | 2022-02-19 | Kansas State (65) | 79 | 82 | Oklahoma State (66) | Final | W | 3 |
| 29 | 2022-02-21 | Baylor (5) | 66 | 64 | Oklahoma State (65) | Final | L | -2 |
| 30 | 2022-02-26 | Oklahoma State (65) | 62 | 66 | Oklahoma (54) | Final | L | -4 |
| 31 | 2022-03-02 | Oklahoma State (71) | 53 | 36 | Iowa State (29) | Final | W | 17 |
| 32 | 2022-03-05 | Texas Tech (12) | 51 | 52 | Oklahoma State (71) | Final | W | 1 |