Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2023-11-06 | UMBC (321) | 93 | 94 | Louisville (153) | Final | W | 1 |
| 2 | 2023-11-10 | Chattanooga (64) | 81 | 71 | Louisville (192) | Final | L | -10 |
| 3 | 2023-11-15 | Coppin State (360) | 41 | 61 | Louisville (164) | Final | W | 20 |
| 4 | 2023-11-19 | Texas (26) | 81 | 80 | Louisville (166) | Final | L | -1 |
| 5 | 2023-11-20 | Indiana (98) | 74 | 66 | Louisville (208) | Final | L | -8 |
| 6 | 2023-11-26 | New Mexico State (300) | 84 | 90 | Louisville (183) | Final | W | 6 |
| 7 | 2023-11-29 | Bellarmine (288) | 68 | 73 | Louisville (185) | Final | W | 5 |
| 8 | 2023-12-03 | Louisville (204) | 68 | 75 | Virginia Tech (62) | Final | L | -7 |
| 9 | 2023-12-09 | Louisville (232) | 68 | 75 | DePaul (226) | Final | L | -7 |
| 10 | 2023-12-13 | Arkansas State (258) | 75 | 63 | Louisville (263) | Final | L | -12 |
| 11 | 2023-12-17 | Pepperdine (265) | 63 | 85 | Louisville (230) | Final | W | 22 |
| 12 | 2023-12-21 | Kentucky (18) | 95 | 76 | Louisville (236) | Final | L | -19 |
| 13 | 2024-01-03 | Louisville (239) | 53 | 77 | Virginia (50) | Final | L | -24 |
| 14 | 2024-01-06 | Pittsburgh (68) | 83 | 70 | Louisville (244) | Final | L | -13 |
| 15 | 2024-01-10 | Louisville (213) | 80 | 71 | Miami (46) | Final | W | 9 |
| 16 | 2024-01-13 | North Carolina State (55) | 89 | 83 | Louisville (210) | Final | L | -6 |
| 17 | 2024-01-17 | Louisville (222) | 70 | 86 | North Carolina (5) | Final | L | -16 |
| 18 | 2024-01-20 | Louisville (214) | 65 | 90 | Wake Forest (37) | Final | L | -25 |
| 19 | 2024-01-23 | Duke (27) | 83 | 69 | Louisville (215) | Final | L | -14 |
| 20 | 2024-01-27 | Virginia (45) | 69 | 52 | Louisville (223) | Final | L | -17 |
| 21 | 2024-01-30 | Louisville (227) | 64 | 70 | Clemson (29) | Final | L | -6 |
| 22 | 2024-02-03 | Florida State (76) | 92 | 101 | Louisville (191) | Final | W | 9 |
| 23 | 2024-02-07 | Louisville (190) | 92 | 94 | Syracuse (59) | Final | L | -2 |
| 24 | 2024-02-10 | Georgia Tech (125) | 67 | 79 | Louisville (170) | Final | W | 12 |
| 25 | 2024-02-13 | Louisville (176) | 77 | 89 | Boston College (87) | Final | L | -12 |
| 26 | 2024-02-17 | Louisville (180) | 59 | 86 | Pittsburgh (49) | Final | L | -27 |
| 27 | 2024-02-21 | Notre Dame (143) | 72 | 50 | Louisville (203) | Final | L | -22 |
| 28 | 2024-02-28 | Louisville (197) | 59 | 84 | Duke (12) | Final | L | -25 |
| 29 | 2024-03-02 | Syracuse (54) | 82 | 76 | Louisville (200) | Final | L | -6 |
| 30 | 2024-03-05 | Virginia Tech (64) | 80 | 64 | Louisville (203) | Final | L | -16 |
| 31 | 2024-03-09 | Boston College (92) | 67 | 61 | Louisville (208) | Final | L | -6 |
| 32 | 2024-03-12 | Louisville (209) | 85 | 94 | North Carolina State (75) | Final | L | -9 |