Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-11-07 | Winthrop (257) | 68 | 93 | Penn State (54) | Final | W | 25 |
| 2 | 2022-11-10 | Loyola-Maryland (328) | 65 | 90 | Penn State (54) | Final | W | 25 |
| 3 | 2022-11-14 | Butler (104) | 62 | 68 | Penn State (54) | Final | W | 6 |
| 4 | 2022-11-17 | Furman (105) | 68 | 73 | Penn State (54) | Final | W | 5 |
| 5 | 2022-11-18 | Penn State (54) | 59 | 61 | Virginia Tech (66) | Final | L | -2 |
| 6 | 2022-11-20 | Penn State (54) | 68 | 56 | Colorado State (135) | Final | W | 12 |
| 7 | 2022-11-25 | Lafayette (298) | 57 | 70 | Penn State (54) | Final | W | 13 |
| 8 | 2022-11-29 | Penn State (54) | 94 | 101 | Clemson (63) | Final | L | -7 |
| 9 | 2022-12-07 | Michigan State (41) | 67 | 58 | Penn State (54) | Final | L | -9 |
| 10 | 2022-12-10 | Penn State (54) | 74 | 59 | Illinois (34) | Final | W | 15 |
| 11 | 2022-12-18 | Canisius (308) | 67 | 97 | Penn State (54) | Final | W | 30 |
| 12 | 2022-12-22 | Quinnipiac (150) | 68 | 77 | Penn State (54) | Final | W | 9 |
| 13 | 2022-12-29 | Delaware State (356) | 46 | 60 | Penn State (54) | Final | W | 14 |
| 14 | 2023-01-01 | Iowa (43) | 79 | 83 | Penn State (54) | Final | W | 4 |
| 15 | 2023-01-04 | Penn State (54) | 69 | 79 | Michigan (55) | Final | L | -10 |
| 16 | 2023-01-08 | Purdue (4) | 76 | 63 | Penn State (54) | Final | L | -13 |
| 17 | 2023-01-11 | Indiana (19) | 66 | 85 | Penn State (54) | Final | W | 19 |
| 18 | 2023-01-17 | Penn State (54) | 60 | 63 | Wisconsin (53) | Final | L | -3 |
| 19 | 2023-01-21 | Nebraska (83) | 65 | 76 | Penn State (54) | Final | W | 11 |
| 20 | 2023-01-24 | Penn State (54) | 45 | 65 | Rutgers (40) | Final | L | -20 |
| 21 | 2023-01-29 | Michigan (55) | 61 | 83 | Penn State (54) | Final | W | 22 |
| 22 | 2023-02-01 | Penn State (54) | 60 | 80 | Purdue (4) | Final | L | -20 |
| 23 | 2023-02-05 | Penn State (54) | 63 | 72 | Nebraska (83) | Final | L | -9 |
| 24 | 2023-02-08 | Wisconsin (53) | 79 | 74 | Penn State (54) | Final | L | -5 |
| 25 | 2023-02-11 | Penn State (54) | 68 | 74 | Maryland (28) | Final | L | -6 |
| 26 | 2023-02-14 | Illinois (34) | 81 | 93 | Penn State (54) | Final | W | 12 |
| 27 | 2023-02-18 | Penn State (54) | 76 | 69 | Minnesota (214) | Final | W | 7 |
| 28 | 2023-02-23 | Penn State (54) | 75 | 71 | Ohio State (97) | Final | W | 4 |
| 29 | 2023-02-26 | Rutgers (45) | 59 | 56 | Penn State (57) | Final | L | -3 |
| 30 | 2023-03-01 | Penn State (54) | 68 | 65 | Northwestern (43) | Final | W | 3 |
| 31 | 2023-03-05 | Maryland (36) | 64 | 65 | Penn State (48) | Final | W | 1 |
| 32 | 2023-03-09 | Penn State (49) | 79 | 76 | Illinois (38) | Final | W | 3 |
| 33 | 2023-03-10 | Penn State (49) | 67 | 65 | Northwestern (39) | Final | W | 2 |
| 34 | 2023-03-11 | Penn State (40) | 77 | 73 | Indiana (24) | Final | W | 4 |
| 35 | 2023-03-12 | Penn State (41) | 65 | 67 | Purdue (3) | Final | L | -2 |
| 36 | 2023-03-16 | Penn State | 76 | 59 | Texas A&M | Final | W | 17 |
| 37 | 2023-03-18 | Penn State (41) | 66 | 71 | Texas (7) | Final | L | -5 |