Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-11-07 | Northern Colorado (270) | 36 | 83 | Houston (1) | Final | W | 47 |
| 2 | 2022-11-11 | Houston (1) | 81 | 55 | Saint Joseph's (170) | Final | W | 26 |
| 3 | 2022-11-14 | Oral Roberts (51) | 45 | 83 | Houston (1) | Final | W | 38 |
| 4 | 2022-11-16 | Texas Southern (316) | 48 | 83 | Houston (1) | Final | W | 35 |
| 5 | 2022-11-20 | Houston (1) | 66 | 56 | Oregon (60) | Final | W | 10 |
| 6 | 2022-11-26 | Kent State (67) | 44 | 49 | Houston (1) | Final | W | 5 |
| 7 | 2022-11-29 | Norfolk State (143) | 52 | 100 | Houston (1) | Final | W | 48 |
| 8 | 2022-12-03 | Saint Mary's (12) | 48 | 53 | Houston (1) | Final | W | 5 |
| 9 | 2022-12-06 | North Florida (247) | 42 | 76 | Houston (1) | Final | W | 34 |
| 10 | 2022-12-10 | Alabama (2) | 71 | 65 | Houston (1) | Final | L | -6 |
| 11 | 2022-12-13 | North Carolina A&T (280) | 46 | 74 | Houston (1) | Final | W | 28 |
| 12 | 2022-12-17 | Houston (1) | 69 | 61 | Virginia (11) | Final | W | 8 |
| 13 | 2022-12-21 | McNeese State (334) | 44 | 83 | Houston (1) | Final | W | 39 |
| 14 | 2022-12-28 | Houston (1) | 89 | 50 | Tulsa (306) | Final | W | 39 |
| 15 | 2022-12-31 | Central Florida (71) | 65 | 71 | Houston (1) | Final | W | 6 |
| 16 | 2023-01-05 | SMU (181) | 53 | 87 | Houston (1) | Final | W | 34 |
| 17 | 2023-01-08 | Houston (1) | 72 | 59 | Cincinnati (74) | Final | W | 13 |
| 18 | 2023-01-11 | South Florida (169) | 77 | 83 | Houston (1) | Final | W | 6 |
| 19 | 2023-01-17 | Houston (1) | 80 | 60 | Tulane (72) | Final | W | 20 |
| 20 | 2023-01-22 | Temple (108) | 56 | 55 | Houston (1) | Final | L | -1 |
| 21 | 2023-01-25 | Houston (1) | 82 | 71 | Central Florida (71) | Final | W | 11 |
| 22 | 2023-01-28 | Cincinnati (74) | 69 | 75 | Houston (1) | Final | W | 6 |
| 23 | 2023-02-02 | Houston (1) | 70 | 61 | Wichita State (118) | Final | W | 9 |
| 24 | 2023-02-05 | Houston (1) | 81 | 65 | Temple (108) | Final | W | 16 |
| 25 | 2023-02-08 | Tulsa (306) | 42 | 80 | Houston (1) | Final | W | 38 |
| 26 | 2023-02-16 | Houston (1) | 80 | 65 | SMU (181) | Final | W | 15 |
| 27 | 2023-02-19 | Memphis (36) | 64 | 72 | Houston (1) | Final | W | 8 |
| 28 | 2023-02-22 | Tulane (72) | 59 | 89 | Houston (1) | Final | W | 30 |
| 29 | 2023-02-25 | Houston (1) | 76 | 57 | East Carolina (177) | Final | W | 19 |
| 30 | 2023-03-02 | Wichita State (112) | 66 | 83 | Houston (1) | Final | W | 17 |
| 31 | 2023-03-05 | Houston (1) | 67 | 65 | Memphis (31) | Final | W | 2 |
| 32 | 2023-03-10 | East Carolina (160) | 46 | 60 | Houston (1) | Final | W | 14 |
| 33 | 2023-03-11 | Cincinnati (66) | 48 | 69 | Houston (1) | Final | W | 21 |
| 34 | 2023-03-12 | Memphis (20) | 75 | 65 | Houston (2) | Final | L | -10 |
| 35 | 2023-03-16 | Northern Kentucky | 52 | 63 | Houston | Final | W | 11 |
| 36 | 2023-03-18 | Auburn (34) | 64 | 81 | Houston (2) | Final | W | 17 |
| 37 | 2023-03-24 | Miami (23) | 89 | 75 | Houston (2) | Final | L | -14 |