Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2022-11-08 | Mercer (264) | 75 | 77 | East Carolina (185) | Final | W | 2 |
| 2 | 2022-11-12 | Presbyterian (357) | 57 | 77 | East Carolina (185) | Final | W | 20 |
| 3 | 2022-11-16 | Hampton (337) | 73 | 82 | East Carolina (185) | Final | W | 9 |
| 4 | 2022-11-21 | Indiana State (114) | 79 | 75 | East Carolina (185) | Final | L | -4 |
| 5 | 2022-11-22 | East Carolina (185) | 86 | 75 | Toledo (100) | Final | W | 11 |
| 6 | 2022-11-23 | Texas-Arlington (238) | 65 | 79 | East Carolina (185) | Final | W | 14 |
| 7 | 2022-11-26 | East Carolina (185) | 50 | 71 | Old Dominion (141) | Final | L | -21 |
| 8 | 2022-11-29 | South Carolina State (350) | 73 | 68 | East Carolina (185) | Final | L | -5 |
| 9 | 2022-12-02 | Campbell (255) | 69 | 79 | East Carolina (185) | Final | W | 10 |
| 10 | 2022-12-06 | East Carolina (185) | 61 | 74 | UNC-Wilmington (117) | Final | L | -13 |
| 11 | 2022-12-11 | Coppin State (346) | 75 | 84 | East Carolina (185) | Final | W | 9 |
| 12 | 2022-12-17 | East Carolina (185) | 64 | 56 | South Carolina (197) | Final | W | 8 |
| 13 | 2022-12-21 | High Point (276) | 49 | 60 | East Carolina (185) | Final | W | 11 |
| 14 | 2022-12-28 | Temple (108) | 59 | 57 | East Carolina (185) | Final | L | -2 |
| 15 | 2022-12-31 | East Carolina (185) | 79 | 69 | Wichita State (118) | Final | W | 10 |
| 16 | 2023-01-04 | Central Florida (71) | 64 | 61 | East Carolina (185) | Final | L | -3 |
| 17 | 2023-01-07 | East Carolina (185) | 59 | 69 | Memphis (36) | Final | L | -10 |
| 18 | 2023-01-11 | East Carolina (185) | 55 | 83 | Cincinnati (74) | Final | L | -28 |
| 19 | 2023-01-15 | South Florida (169) | 81 | 70 | East Carolina (185) | Final | L | -11 |
| 20 | 2023-01-18 | East Carolina (185) | 58 | 73 | Temple (108) | Final | L | -15 |
| 21 | 2023-01-24 | Tulsa (306) | 66 | 76 | East Carolina (185) | Final | W | 10 |
| 22 | 2023-01-29 | Wichita State (118) | 85 | 72 | East Carolina (185) | Final | L | -13 |
| 23 | 2023-02-01 | East Carolina (185) | 63 | 71 | South Florida (169) | Final | L | -8 |
| 24 | 2023-02-04 | SMU (181) | 72 | 77 | East Carolina (185) | Final | W | 5 |
| 25 | 2023-02-15 | Cincinnati (74) | 71 | 75 | East Carolina (185) | Final | W | 4 |
| 26 | 2023-02-19 | East Carolina (185) | 70 | 86 | SMU (181) | Final | L | -16 |
| 27 | 2023-02-21 | East Carolina (185) | 62 | 60 | Tulsa (306) | Final | W | 2 |
| 28 | 2023-02-25 | Houston (1) | 76 | 57 | East Carolina (177) | Final | L | -19 |
| 29 | 2023-03-01 | Tulane (92) | 68 | 83 | East Carolina (165) | Final | W | 15 |
| 30 | 2023-03-03 | East Carolina (163) | 78 | 81 | Tulane (92) | Final | L | -3 |
| 31 | 2023-03-05 | East Carolina (172) | 58 | 84 | Central Florida (77) | Final | L | -26 |
| 32 | 2023-03-09 | East Carolina (160) | 73 | 58 | South Florida (158) | Final | W | 15 |
| 33 | 2023-03-10 | East Carolina (160) | 46 | 60 | Houston (1) | Final | L | -14 |