Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-27 | East Carolina (216) | 66 | 57 | Charlotte (170) | Final | W | 9 |
| 2 | 2020-11-28 | East Carolina (216) | Belmont Abbey | Scheduled – 03:00PM ET | – | – | ||
| 3 | 2020-12-01 | North Carolina Wesleyan | 62 | 91 | East Carolina (70) | Final | W | 29 |
| 4 | 2020-12-05 | Radford (335) | 50 | 63 | East Carolina (70) | Final | W | 13 |
| 5 | 2020-12-07 | UNC-Wilmington (103) | 78 | 88 | East Carolina (70) | Final (OT) | W | 10 |
| 6 | 2020-12-10 | North Florida (350) | 67 | 73 | East Carolina (85) | Final | W | 6 |
| 7 | 2020-12-16 | East Carolina (54) | 55 | 70 | SMU (20) | Final | L | -15 |
| 8 | 2020-12-19 | James Madison (220) | 64 | 73 | East Carolina (54) | Final | W | 9 |
| 9 | 2020-12-22 | Tulane (111) | 58 | 68 | East Carolina (67) | Final | W | 10 |
| 10 | 2020-12-30 | East Carolina (55) | 0 | 0 | Wichita State (92) | Scheduled – 07:00PM ET | – | – |
| 11 | 2021-01-02 | East Carolina (55) | 56 | 60 | Tulane (141) | Final | L | -4 |
| 12 | 2021-01-09 | South Florida (108) | 69 | 63 | East Carolina (77) | Final | L | -6 |
| 13 | 2021-01-13 | East Carolina (113) | 0 | 0 | Cincinnati (132) | Scheduled – 05:00PM ET | – | – |
| 14 | 2021-01-16 | Temple (155) | 0 | 0 | East Carolina (113) | Scheduled – 12:00PM ET | – | – |
| 15 | 2021-01-20 | East Carolina (117) | 0 | 0 | South Florida (116) | Scheduled – 07:00PM ET | – | – |
| 16 | 2021-01-24 | Memphis (72) | 80 | 53 | East Carolina (134) | Final | L | -27 |
| 17 | 2021-01-27 | East Carolina (134) | 64 | 71 | Central Florida (102) | Final | L | -7 |
| 18 | 2021-01-30 | Tulsa (69) | 77 | 68 | East Carolina (134) | Final | L | -9 |
| 19 | 2021-02-03 | Houston (3) | 73 | 82 | East Carolina (145) | Final | W | 9 |
| 20 | 2021-02-06 | East Carolina (145) | 59 | 66 | Memphis (69) | Final | L | -7 |
| 21 | 2021-02-08 | SMU (42) | 71 | 56 | East Carolina (135) | Final | L | -15 |
| 22 | 2021-02-11 | East Carolina (135) | 0 | 0 | Temple (144) | Scheduled – 12:00PM ET | – | – |
| 23 | 2021-02-13 | Temple (144) | 0 | 0 | East Carolina (135) | Scheduled – 12:00PM ET | – | – |
| 24 | 2021-02-17 | East Carolina (142) | 0 | 0 | Houston (4) | Scheduled – 08:00PM ET | – | – |
| 25 | 2021-02-21 | Wichita State (49) | 0 | 0 | East Carolina (142) | Scheduled – 12:00PM ET | – | – |
| 26 | 2021-02-27 | East Carolina (142) | 0 | 0 | Tulsa (100) | Scheduled – 07:00PM ET | – | – |
| 27 | 2021-03-04 | Central Florida (103) | 64 | 60 | East Carolina (142) | Final | L | -4 |
| 28 | 2021-03-07 | Cincinnati (113) | 82 | 69 | East Carolina (162) | Final | L | -13 |
| 29 | 2021-03-11 | East Carolina (162) | 62 | 72 | Central Florida (100) | Final | L | -10 |