Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-03 | St. Thomas (TX) | 0 | 0 | Lamar | Scheduled – | – | – |
| 2 | 2021-11-09 | Wiley | 50 | 67 | Lamar (295) | Final | W | 17 |
| 3 | 2021-11-13 | Lamar (295) | 75 | 104 | Miami (OH) (193) | Final | L | -29 |
| 4 | 2021-11-15 | Lamar (269) | 66 | 75 | Georgia Tech (148) | Final | L | -9 |
| 5 | 2021-11-19 | Stetson (312) | 60 | 59 | Lamar (269) | Final | L | -1 |
| 6 | 2021-11-21 | Lamar (347) | 75 | 82 | Southern Miss (278) | Final | L | -7 |
| 7 | 2021-11-24 | Lamar (347) | 73 | 79 | UTSA (335) | Final | L | -6 |
| 8 | 2021-11-27 | Lamar (347) | 57 | 89 | Texas Tech (73) | Final | L | -32 |
| 9 | 2021-12-02 | Lamar (349) | 60 | 75 | Mississippi State (40) | Final | L | -15 |
| 10 | 2021-12-05 | Lady of the Lake | 64 | 67 | Lamar (349) | Final | W | 3 |
| 11 | 2021-12-11 | Lamar (348) | 47 | 56 | Texas-Arlington (282) | Final | L | -9 |
| 12 | 2021-12-15 | Lamar (351) | 47 | 67 | Texas State (103) | Final | L | -20 |
| 13 | 2021-12-18 | Lamar (351) | 53 | 57 | Texas A&M-Corpus Christi (131) | Final | L | -4 |
| 14 | 2021-12-20 | Louisiana-Monroe (173) | 80 | 77 | Lamar (352) | Final | L | -3 |
| 15 | 2021-12-30 | Lamar (350) | 64 | 75 | Sam Houston State (278) | Final | L | -11 |
| 16 | 2022-01-06 | New Mexico State (74) | 0 | 0 | Lamar (352) | Scheduled – 08:00PM ET | – | – |
| 17 | 2022-01-08 | Grand Canyon (88) | 0 | 0 | Lamar (352) | Scheduled – 04:00PM ET | – | – |
| 18 | 2022-01-13 | Sam Houston State (255) | 73 | 56 | Lamar (353) | Final | L | -17 |
| 19 | 2022-01-15 | Chicago State (312) | 67 | 56 | Lamar (353) | Final | L | -11 |
| 20 | 2022-01-17 | Lamar (354) | 78 | 86 | Stephen F. Austin (178) | Final | L | -8 |
| 21 | 2022-01-20 | Lamar (354) | 55 | 71 | Dixie State (274) | Final | L | -16 |
| 22 | 2022-01-22 | Lamar (354) | 41 | 58 | Utah Valley (127) | Final | L | -17 |
| 23 | 2022-01-26 | Tarleton State (235) | 62 | 57 | Lamar (353) | Final | L | -5 |
| 24 | 2022-01-29 | Abilene Christian (137) | 85 | 82 | Lamar (355) | Final | L | -3 |
| 25 | 2022-02-02 | Lamar (355) | 79 | 93 | UTRGV (303) | Final | L | -14 |
| 26 | 2022-02-10 | Lamar (355) | 61 | 83 | California Baptist (217) | Final | L | -22 |
| 27 | 2022-02-12 | Lamar (355) | 50 | 76 | Seattle (111) | Final | L | -26 |
| 28 | 2022-02-19 | Stephen F. Austin (129) | 70 | 56 | Lamar (355) | Final | L | -14 |
| 29 | 2022-02-24 | Lamar (355) | 42 | 77 | Abilene Christian (135) | Final | L | -35 |
| 30 | 2022-02-26 | Lamar (355) | 49 | 57 | Tarleton State (230) | Final | L | -8 |
| 31 | 2022-03-02 | UTRGV (318) | 67 | 63 | Lamar (355) | Final | L | -4 |
| 32 | 2022-03-05 | California Baptist (213) | 78 | 66 | Lamar (355) | Final | L | -12 |