Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2020-11-30 | Liberty (77) | Siena (160) | Scheduled – 02:00PM ET | – | – | ||
| 2 | 2020-12-11 | Siena (201) | 0 | 0 | Fairfield (348) | Scheduled – 07:00PM ET | – | – |
| 3 | 2020-12-12 | Siena (201) | 0 | 0 | Fairfield (348) | Scheduled – 07:00PM ET | – | – |
| 4 | 2020-12-18 | Canisius (147) | 0 | 0 | Siena (196) | Scheduled – 05:00PM ET | – | – |
| 5 | 2020-12-19 | Canisius (147) | 0 | 0 | Siena (196) | Scheduled – 05:00PM ET | – | – |
| 6 | 2021-01-03 | Monmouth (128) | 77 | 78 | Siena (191) | Final | W | 1 |
| 7 | 2021-01-04 | Monmouth (128) | 62 | 76 | Siena (191) | Final | W | 14 |
| 8 | 2021-01-08 | Canisius (157) | 0 | 0 | Siena (98) | Scheduled – 05:00PM ET | – | – |
| 9 | 2021-01-09 | Canisius (157) | 0 | 0 | Siena (98) | Scheduled – 05:00PM ET | – | – |
| 10 | 2021-01-09 | Siena (98) | 74 | 58 | Fairfield (336) | Final | W | 16 |
| 11 | 2021-01-10 | Siena (98) | 75 | 68 | Fairfield (336) | Final | W | 7 |
| 12 | 2021-01-15 | Siena (59) | 78 | 69 | Rider (310) | Final | W | 9 |
| 13 | 2021-01-16 | Siena (59) | 74 | 72 | Rider (310) | Final | W | 2 |
| 14 | 2021-01-22 | Saint Peter’s (152) | 68 | 62 | Siena (59) | Final | L | -6 |
| 15 | 2021-01-23 | Saint Peter’s (152) | 40 | 47 | Siena (59) | Final | W | 7 |
| 16 | 2021-01-30 | Siena (81) | 54 | 55 | Marist (235) | Final | L | -1 |
| 17 | 2021-01-31 | Siena (99) | 63 | 50 | Marist (213) | Final | W | 13 |
| 18 | 2021-02-03 | Canisius (183) | 0 | 0 | Siena (99) | Scheduled – 07:00PM ET | – | – |
| 19 | 2021-02-12 | Canisius (178) | 0 | 0 | Siena (102) | Scheduled – 06:00PM ET | – | – |
| 20 | 2021-02-13 | Canisius (178) | 0 | 0 | Siena (102) | Scheduled – 01:00PM ET | – | – |
| 21 | 2021-02-20 | Siena (100) | 62 | 64 | Niagara (230) | Final | L | -2 |
| 22 | 2021-02-20 | Manhattan (265) | 0 | 0 | Siena (100) | Scheduled – 01:00PM ET | – | – |
| 23 | 2021-02-21 | Siena (128) | 68 | 66 | Niagara (224) | Final | W | 2 |
| 24 | 2021-02-24 | Quinnipiac | 0 | 0 | Siena | Scheduled – 07:00PM ET | – | – |
| 25 | 2021-02-26 | Manhattan (267) | 69 | 74 | Siena (128) | Final | W | 5 |
| 26 | 2021-02-27 | Siena | 0 | 0 | Iona | Scheduled – 02:00PM ET | – | – |
| 27 | 2021-02-27 | Manhattan (267) | 56 | 64 | Siena (128) | Final | W | 8 |
| 28 | 2021-02-28 | Siena | 0 | 0 | Iona | Scheduled – 06:00PM ET | – | – |
| 29 | 2021-03-04 | Canisius (182) | 64 | 73 | Siena (126) | Final | W | 9 |
| 30 | 2021-03-05 | Quinnipiac (239) | 0 | 0 | Siena (126) | Scheduled – 07:00PM ET | – | – |
| 31 | 2021-03-05 | Canisius (182) | 76 | 75 | Siena (126) | Final | L | -1 |
| 32 | 2021-03-10 | Iona (166) | 55 | 52 | Siena (124) | Final | L | -3 |