Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-01 | Missouri Southern State | 58 | 90 | Wichita State (47) | Final | W | 32 |
| 2 | 2021-11-09 | Jacksonville State (152) | 57 | 60 | Wichita State (47) | Final | W | 3 |
| 3 | 2021-11-13 | South Alabama (178) | 58 | 64 | Wichita State (47) | Final | W | 6 |
| 4 | 2021-11-16 | Tarleton State (326) | 51 | 65 | Wichita State (21) | Final | W | 14 |
| 5 | 2021-11-19 | Wichita State (21) | 78 | 82 | Arizona (25) | Final (OT) | L | -4 |
| 6 | 2021-11-22 | Wichita State (77) | 74 | 73 | UNLV (104) | Final | W | 1 |
| 7 | 2021-11-26 | Wichita State (77) | 61 | 55 | Missouri (105) | Final | W | 6 |
| 8 | 2021-12-01 | Wichita State (41) | 60 | 51 | Oklahoma State (25) | Final | W | 9 |
| 9 | 2021-12-05 | Kansas State (145) | 65 | 59 | Wichita State (41) | Final | L | -6 |
| 10 | 2021-12-11 | Norfolk State (148) | 58 | 71 | Wichita State (60) | Final | W | 13 |
| 11 | 2021-12-14 | Alcorn State (304) | 63 | 82 | Wichita State (49) | Final | W | 19 |
| 12 | 2021-12-18 | North Texas (118) | 62 | 52 | Wichita State (49) | Final | L | -10 |
| 13 | 2021-12-22 | Prairie View A&M (333) | 66 | 102 | Wichita State (62) | Final | W | 36 |
| 14 | 2021-12-29 | Wichita State (62) | 0 | 0 | East Carolina (113) | Scheduled – 07:00PM ET | – | – |
| 15 | 2022-01-01 | Memphis (59) | 82 | 64 | Wichita State (62) | Final | L | -18 |
| 16 | 2022-01-08 | Wichita State (77) | 66 | 76 | Houston (14) | Final | L | -10 |
| 17 | 2022-01-12 | Tulane (151) | 68 | 67 | Wichita State (78) | Final | L | -1 |
| 18 | 2022-01-16 | Cincinnati (70) | 61 | 57 | Wichita State (96) | Final | L | -4 |
| 19 | 2022-01-19 | Wichita State (96) | 0 | 0 | Temple (102) | Scheduled – 07:00PM ET | – | – |
| 20 | 2022-01-26 | Central Florida (70) | 79 | 84 | Wichita State (90) | Final | W | 5 |
| 21 | 2022-01-29 | Wichita State (88) | 66 | 67 | Tulane (125) | Final | L | -1 |
| 22 | 2022-02-01 | Tulsa (188) | 48 | 58 | Wichita State (88) | Final | W | 10 |
| 23 | 2022-02-03 | Wichita State (88) | 0 | 0 | SMU (49) | Scheduled – | – | – |
| 24 | 2022-02-05 | SMU (49) | 57 | 72 | Wichita State (88) | Final | W | 15 |
| 25 | 2022-02-08 | Wichita State (78) | 66 | 71 | Central Florida (93) | Final | L | -5 |
| 26 | 2022-02-12 | South Florida (239) | 69 | 73 | Wichita State (78) | Final | W | 4 |
| 27 | 2022-02-17 | Wichita State (84) | 76 | 85 | Cincinnati (90) | Final | L | -9 |
| 28 | 2022-02-20 | Houston (13) | 76 | 74 | Wichita State (86) | Final | L | -2 |
| 29 | 2022-02-27 | Wichita State (100) | 57 | 81 | Memphis (47) | Final | L | -24 |
| 30 | 2022-03-02 | Wichita State (100) | 72 | 62 | Tulsa (202) | Final | W | 10 |
| 31 | 2022-03-05 | East Carolina (137) | 62 | 70 | Wichita State (100) | Final | W | 8 |
| 32 | 2022-03-10 | Tulsa (197) | 73 | 67 | Wichita State (90) | Final | L | -6 |