Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-10 | Alcorn State (329) | 66 | 69 | Seattle (237) | Final | W | 3 |
| 2 | 2021-11-12 | Seattle (237) | 61 | 79 | Washington State (101) | Final | L | -18 |
| 3 | 2021-11-14 | Idaho State (346) | 51 | 77 | Seattle (149) | Final | W | 26 |
| 4 | 2021-11-18 | Morgan State (180) | 80 | 93 | Seattle (149) | Final | W | 13 |
| 5 | 2021-11-22 | Arkansas-Pine Bluff (317) | 56 | 77 | Seattle (107) | Final | W | 21 |
| 6 | 2021-11-23 | Pacific Lutheran | 40 | 89 | Seattle (107) | Final | W | 49 |
| 7 | 2021-11-27 | St. Thomas (217) | 64 | 81 | Seattle (107) | Final | W | 17 |
| 8 | 2021-12-01 | McNeese State (271) | 62 | 78 | Seattle (101) | Final | W | 16 |
| 9 | 2021-12-05 | Virginia Military (273) | 89 | 82 | Seattle (101) | Final | L | -7 |
| 10 | 2021-12-08 | Seattle (141) | 56 | 76 | UNLV (165) | Final | L | -20 |
| 11 | 2021-12-12 | UC-San Diego (182) | 51 | 73 | Seattle (150) | Final | W | 22 |
| 12 | 2021-12-18 | Seattle (150) | 56 | 64 | Washington (187) | Final | L | -8 |
| 13 | 2021-12-22 | Northwest (WA) | 68 | 100 | Seattle (181) | Final | W | 32 |
| 14 | 2022-01-06 | Seattle (167) | 93 | 77 | Chicago State (326) | Final | W | 16 |
| 15 | 2022-01-12 | Utah Valley (104) | 65 | 71 | Seattle (157) | Final | W | 6 |
| 16 | 2022-01-15 | Dixie State (279) | 68 | 79 | Seattle (157) | Final | W | 11 |
| 17 | 2022-01-17 | Seattle (137) | 92 | 85 | California Baptist (170) | Final (OT) | W | 7 |
| 18 | 2022-01-20 | Seattle (137) | 72 | 62 | Abilene Christian (139) | Final | W | 10 |
| 19 | 2022-01-22 | Seattle (137) | 76 | 68 | Tarleton State (230) | Final | W | 8 |
| 20 | 2022-01-26 | Stephen F. Austin (159) | 62 | 70 | Seattle (114) | Final | W | 8 |
| 21 | 2022-01-29 | Sam Houston State (184) | 63 | 78 | Seattle (102) | Final | W | 15 |
| 22 | 2022-02-03 | Seattle (102) | 66 | 78 | Grand Canyon (111) | Final | L | -12 |
| 23 | 2022-02-05 | Seattle (102) | 64 | 79 | New Mexico State (80) | Final | L | -15 |
| 24 | 2022-02-10 | UTRGV (305) | 59 | 67 | Seattle (111) | Final | W | 8 |
| 25 | 2022-02-12 | Lamar (355) | 50 | 76 | Seattle (111) | Final | W | 26 |
| 26 | 2022-02-16 | Seattle (111) | 102 | 62 | UTRGV (309) | Final | W | 40 |
| 27 | 2022-02-19 | California Baptist (211) | 64 | 67 | Seattle (111) | Final | W | 3 |
| 28 | 2022-02-21 | New Mexico State (62) | 68 | 55 | Seattle (106) | Final | L | -13 |
| 29 | 2022-02-24 | Seattle (106) | 52 | 67 | Utah Valley (127) | Final | L | -15 |
| 30 | 2022-02-26 | Seattle (106) | 73 | 65 | Dixie State (239) | Final | W | 8 |
| 31 | 2022-03-05 | Chicago State (333) | 66 | 74 | Seattle (113) | Final | W | 8 |
| 32 | 2022-03-11 | Abilene Christian (129) | 78 | 76 | Seattle (112) | Final | L | -2 |