Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | UMBC (136) | 60 | 77 | Massachusetts (129) | Final | W | 17 |
| 2 | 2021-11-12 | Massachusetts (129) | 71 | 91 | Yale | Final | L | -20 |
| 3 | 2021-11-15 | Penn State (76) | 56 | 81 | Massachusetts (206) | Final | W | 25 |
| 4 | 2021-11-18 | Massachusetts (206) | 73 | 88 | Weber State (159) | Final | L | -15 |
| 5 | 2021-11-19 | UNC-Greensboro (92) | 90 | 93 | Massachusetts (206) | Final (OT) | W | 3 |
| 6 | 2021-11-21 | Ball State (214) | 89 | 86 | Massachusetts (162) | Final | L | -3 |
| 7 | 2021-11-24 | UMass-Lowell (138) | 81 | 92 | Massachusetts (162) | Final | W | 11 |
| 8 | 2021-11-27 | Rutgers (108) | 83 | 85 | Massachusetts (162) | Final | W | 2 |
| 9 | 2021-12-04 | Harvard (165) | 77 | 87 | Massachusetts (99) | Final | W | 10 |
| 10 | 2021-12-07 | Massachusetts (99) | 76 | 82 | Northeastern (168) | Final | L | -6 |
| 11 | 2021-12-11 | North Texas (162) | 66 | 57 | Massachusetts (99) | Final | L | -9 |
| 12 | 2021-12-19 | Fairfield (154) | 73 | 77 | Massachusetts (131) | Final (OT) | W | 4 |
| 13 | 2021-12-22 | NJIT | 0 | 0 | Massachusetts | Scheduled – 07:00PM ET | – | – |
| 14 | 2022-01-05 | Massachusetts (136) | 72 | 80 | Richmond (107) | Final | L | -8 |
| 15 | 2022-01-08 | Duquesne (220) | 78 | 74 | Massachusetts (136) | Final | L | -4 |
| 16 | 2022-01-11 | Massachusetts (161) | 67 | 77 | Davidson (34) | Final | L | -10 |
| 17 | 2022-01-15 | Rhode Island (113) | 81 | 68 | Massachusetts (161) | Final | L | -13 |
| 18 | 2022-01-20 | Saint Louis (54) | 85 | 91 | Massachusetts (180) | Final | W | 6 |
| 19 | 2022-01-23 | Massachusetts (175) | 59 | 90 | Saint Louis (62) | Final | L | -31 |
| 20 | 2022-01-26 | Massachusetts (175) | 77 | 71 | La Salle (245) | Final | W | 6 |
| 21 | 2022-01-30 | George Mason (103) | 72 | 62 | Massachusetts (180) | Final | L | -10 |
| 22 | 2022-02-05 | Massachusetts (180) | 78 | 67 | Rhode Island (123) | Final | W | 11 |
| 23 | 2022-02-09 | George Washington (233) | 77 | 68 | Massachusetts (162) | Final | L | -9 |
| 24 | 2022-02-12 | Saint Joseph’s (153) | 67 | 69 | Massachusetts (162) | Final | W | 2 |
| 25 | 2022-02-16 | Massachusetts (166) | 71 | 83 | St. Bonaventure (77) | Final | L | -12 |
| 26 | 2022-02-19 | La Salle (253) | 74 | 80 | Massachusetts (166) | Final | W | 6 |
| 27 | 2022-02-23 | Massachusetts (167) | 61 | 82 | Dayton (61) | Final | L | -21 |
| 28 | 2022-02-26 | Virginia Commonwealth (47) | 77 | 62 | Massachusetts (167) | Final | L | -15 |
| 29 | 2022-02-28 | Massachusetts (177) | 73 | 85 | Fordham (184) | Final | L | -12 |
| 30 | 2022-03-02 | Fordham (184) | 73 | 81 | Massachusetts (177) | Final | W | 8 |
| 31 | 2022-03-05 | Massachusetts (177) | 83 | 80 | George Mason (119) | Final | W | 3 |
| 32 | 2022-03-10 | Massachusetts (170) | 99 | 88 | George Washington (216) | Final | W | 11 |
| 33 | 2022-03-11 | Massachusetts (170) | 72 | 75 | Dayton (59) | Final | L | -3 |