Schedule:
Please note: All rankings shown are the rankings of the teams on the date that they played one another
| Game | Date | Away Team (Rank) | Away Score | Home Score | Home Team (Rank) | Game Status | Result | Margin |
|---|---|---|---|---|---|---|---|---|
| 1 | 2021-11-09 | Central Connecticut State (299) | 48 | 99 | Connecticut (32) | Final | W | 51 |
| 2 | 2021-11-13 | Coppin State (273) | 54 | 89 | Connecticut (32) | Final | W | 35 |
| 3 | 2021-11-17 | Long Island (332) | 40 | 93 | Connecticut (63) | Final | W | 53 |
| 4 | 2021-11-20 | Binghamton (157) | 63 | 87 | Connecticut (63) | Final | W | 24 |
| 5 | 2021-11-24 | Connecticut (33) | 115 | 109 | Auburn (53) | Final (2OT) | W | 6 |
| 6 | 2021-11-25 | Connecticut (33) | 60 | 64 | Michigan State (66) | Final | L | -4 |
| 7 | 2021-11-26 | Virginia Commonwealth (128) | 63 | 70 | Connecticut (33) | Final (OT) | W | 7 |
| 8 | 2021-11-30 | Maryland-Eastern Shore (264) | 63 | 72 | Connecticut (20) | Final | W | 9 |
| 9 | 2021-12-04 | Grambling (298) | 59 | 88 | Connecticut (20) | Final | W | 29 |
| 10 | 2021-12-08 | Connecticut (17) | 53 | 56 | West Virginia (40) | Final | L | -3 |
| 11 | 2021-12-11 | St. Bonaventure (50) | 64 | 74 | Connecticut (17) | Final | W | 10 |
| 12 | 2021-12-18 | Providence (20) | 57 | 53 | Connecticut (21) | Final | L | -4 |
| 13 | 2021-12-21 | Connecticut (25) | 78 | 70 | Marquette (47) | Final | W | 8 |
| 14 | 2021-12-28 | Connecticut (23) | 0 | 0 | Xavier (21) | Scheduled – 07:00PM ET | – | – |
| 15 | 2022-01-08 | Connecticut (20) | 87 | 90 | Seton Hall (29) | Final | L | -3 |
| 16 | 2022-01-12 | St. John’s (76) | 78 | 86 | Connecticut (25) | Final (OT) | W | 8 |
| 17 | 2022-01-15 | Connecticut (25) | 0 | 0 | Providence (17) | Scheduled – | – | – |
| 18 | 2022-01-18 | Butler (111) | 59 | 76 | Connecticut (21) | Final | W | 17 |
| 19 | 2022-01-20 | Connecticut (21) | 75 | 56 | Butler (111) | Final | W | 19 |
| 20 | 2022-01-25 | Georgetown (178) | 73 | 96 | Connecticut (19) | Final | W | 23 |
| 21 | 2022-01-29 | Connecticut (17) | 57 | 50 | DePaul (98) | Final | W | 7 |
| 22 | 2022-02-01 | Creighton (60) | 59 | 55 | Connecticut (17) | Final | L | -4 |
| 23 | 2022-02-05 | Connecticut (17) | 74 | 85 | Villanova (13) | Final | L | -11 |
| 24 | 2022-02-08 | Marquette (19) | 72 | 80 | Connecticut (23) | Final | W | 8 |
| 25 | 2022-02-13 | Connecticut (24) | 63 | 60 | St. John’s (85) | Final | W | 3 |
| 26 | 2022-02-16 | Seton Hall (32) | 65 | 70 | Connecticut (24) | Final | W | 5 |
| 27 | 2022-02-19 | Xavier (25) | 61 | 72 | Connecticut (24) | Final | W | 11 |
| 28 | 2022-02-22 | Villanova (9) | 69 | 71 | Connecticut (17) | Final | W | 2 |
| 29 | 2022-02-27 | Connecticut (16) | 86 | 77 | Georgetown (205) | Final | W | 9 |
| 30 | 2022-03-02 | Connecticut (16) | 62 | 64 | Creighton (42) | Final | L | -2 |
| 31 | 2022-03-05 | DePaul (93) | 68 | 75 | Connecticut (16) | Final | W | 7 |
| 32 | 2022-03-10 | Seton Hall (27) | 52 | 62 | Connecticut (18) | Final | W | 10 |
| 33 | 2022-03-11 | Connecticut (18) | 60 | 63 | Villanova (8) | Final | L | -3 |
| 34 | 2022-03-17 | New Mexico State (68) | 70 | 63 | Connecticut (17) | Final | L | -7 |